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Merck
  • Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.

Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production.

The FEBS journal (2010-03-30)
Kevin Bonham, Saskia Hemmers, Yeon-Hee Lim, Dawn M Hill, M G Finn, Kerri A Mowen
摘要

The protein arginine methyltransferase (PRMT) family of enzymes catalyzes the transfer of methyl groups from S-adenosylmethionine to the guanidino nitrogen atom of peptidylarginine to form monomethylarginine or dimethylarginine. We created several less polar analogs of the specific PRMT inhibitor arginine methylation inhibitor-1, and one such compound was found to have improved PRMT inhibitory activity over the parent molecule. The newly identified PRMT inhibitor modulated T-helper-cell function and thus may serve as a lead for further inhibitors useful for the treatment of immune-mediated disease.

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Sigma-Aldrich
西奈芬净, 95% (HPLC), powder
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组蛋白H3肽, This gene contains introns & its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family.
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抗二甲基组蛋白H3(Arg17)抗体, Upstate®, from rabbit