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Merck
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SRP4011

Sigma-Aldrich

Cardiotrophin-1 human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

同義詞:

CT1, CTF1, Cardiophin 1

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About This Item

MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.32

生物源

human

重組細胞

expressed in E. coli

化驗

≥98% (HPLC)
≥98% (SDS-PAGE)

形狀

lyophilized

分子量

~22.5 kDa

包裝

pkg of 10 μg

儲存條件

avoid repeated freeze/thaw cycles

雜質

endotoxin, tested

NCBI登錄號

運輸包裝

wet ice

儲存溫度

−20°C

基因資訊

human ... CTF1(1489)

一般說明

Cardiotrophin-1 belongs to the interleukin-6 (IL-6) family of cytokines. It is a cytoprotective protein. The gene is mapped to human chromosome 16p11.
Recombinant human Cardiotrophin-1 is a 22.5kDa protein containing 200 amino acid residues.

生化/生理作用

Cardiotrophin-1 signals via β receptor glycoprotein 130 (gp130) and β receptor leukemia inhibitory factor receptor (LIFR). It confers protective role on cardiac myocytes. Cardiotrophin-1 protects cardiomyocytes from cell death, however, it can also induce cardiac hypertrophy. It is also involved in neural tissue development and helps in protection of the mature nervous system from injuries and dysfunction. Cardiotrophin-1 also protects liver against injury. It is also involved in the control of body weight and intermediate metabolism. In mouse model, it protects β cells from apoptosis. It also promotes glucose-mediated insulin secretion. Absence of the cardiotrophin-1 gene in mice is associated with obesity, hyperglycemia, hyperinsulinemia and hypercholesterolemia.

外觀

Sterile filtered and then lyophilized in 1 x PBS.

重構

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 20 mM Tris, pH 8.0 to a concentration of <1.0 mg/mL. The solution can be diluted into other aqueous buffers.

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals.
Hung HC, et al.
Scientific Reports, 5, 17438-17438 (2015)
Common genetic variation in the human CTF1 locus, encoding cardiotrophin-1, determines insulin sensitivity.
Lutz SZ, et al.
PLoS ONE, 9, e100391-e100391 (2014)
Cardiotrophin-1: A multifaceted cytokine.
Lopez-Yoldi M, et al.
Cytokine & Growth Factor Reviews, 26, 523-523 (2015)
Alejandro Aranda et al.
Cellular and molecular life sciences : CMLS, 71(23), 4637-4651 (2014-05-06)
We report a new method to generate high-expressing mammalian cell lines in a quick and efficient way. For that purpose, we developed a master cell line (MCL) containing an inducible alphavirus vector expressing GFP integrated into the genome. In the

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