SRP3272

TPO mouse

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

• 同義詞: MGDF, c-MPL Ligand
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 生物源: mouse
• 重組細胞: expressed in E. coli
• 化驗: ≥98% (HPLC); ≥98% (SDS-PAGE)
• 形狀: lyophilized
• 效力: ≥1.0 ng/mL ED₅₀
• 分子量: 18.7 kDa
• 包裝: pkg of 10 μg
• 雜質: <0.1 EU/μg endotoxin, tested
• 顏色: white
• UniProt登錄號: P40226
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: mouse ... Thpo(21832)

描述

一般說明

TPO (thrombopoietin) is a hematopoietic cytokine expressed in multiple tissue types. It is predominantly produced by liver and kidney and acts as a ligand for the cell surface receptor c-mpl.

生化／生理作用

TPO (thrombopoietin) is the key regulator of thrombopoiesis for platelet lineage. In both mice and humans, inactivation of this gene results in significant decrease in number of mature platelets produced by marrow progenitors. Transgenic mice with increased expression of this protein show progressive fibrosis and osteosclerosis of the bone marrow, as well as histological changes in kidneys, leading to mesangioproliferative glomerulopathy.

外觀

Lyophilized from 10 mM Tris, pH 8.0.

重構

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.5-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable