推薦產品
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
2-8°C
InChI
1S/C17H20FNO4S/c1-3-4-7-22-8-9-23-15-11(2)24-16(19-15)12-5-6-13(17(20)21)14(18)10-12/h5-6,10H,3-4,7-9H2,1-2H3,(H,20,21)
InChI 密鑰
HSAOETBFVAWNRP-UHFFFAOYSA-N
生化／生理作用
AC261066 is an orally active, selective and potent synthetic agonist for the retinoic acid β2-receptor (RARβ2) that decreases oxidative stress in mice fed a high-fat diet. AC261066 reduce ischemia/reperfusion injury of the heart in mice models.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Alice Marino et al.
The Journal of pharmacology and experimental therapeutics, 366(2), 314-321 (2018-06-17)
We previously discovered that oral treatment with AC261066, a synthetic selective agonist for the retinoic acid β2-receptor, decreases oxidative stress in the liver, pancreas, and kidney of mice fed a high-fat diet (HFD). Since hyperlipidemic states are causally associated with
Steven E Trasino et al.
Journal of molecular medicine (Berlin, Germany), 94(10), 1143-1151 (2016-06-09)
Hepatic stellate cells (HSCs) are an important cellular target for the development of novel pharmacological therapies to prevent and treat nonalcoholic fatty liver diseases (NAFLD). Using a high fat diet (HFD) model of NAFLD, we sought to determine if synthetic
Discovery of a potent, orally available, and isoform-selective retinoic acid beta2 receptor agonist.
Birgitte W Lund et al.
Journal of medicinal chemistry, 48(24), 7517-7519 (2005-11-24)
4'-Octyl-4-biphenylcarboxylic acid (1g, AC-55649) was identified as a highly isoform-selective agonist at the human RARbeta2 receptor in a functional intact cell-based screening assay. The subsequent hit to lead optimization transformed the lipophilic, poorly soluble hit into a more potent and
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