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Merck
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SML2262

Sigma-Aldrich

拉梅尔通

同義詞:

Ramelteon 溶液, N- [2-[(8S)-1,6,7,8-四氢-2H-茚满[5,4-b]呋喃-8-基]乙基]丙酰胺, TAK 375, TAK-375, (S)-N- [2-(1,6,7,8-四氢-2H-茚基-[5,4-b]呋喃-8-基)乙基]丙酰胺

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About This Item

經驗公式(希爾表示法):
C16H21NO2
CAS號碼:
分子量::
259.34
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

形狀

powder

光學活性

[α]/D -50 to -60°, c = 1.0 in chloroform-d

顏色

white to beige

溶解度

DMSO: 2 mg/mL, clear

儲存溫度

2-8°C

SMILES 字串

CCC(NCC[C@H]1C(C(CCO2)=C2C=C3)=C3CC1)=O

InChI

1S/C16H21NO2/c1-2-15(18)17-9-7-12-4-3-11-5-6-14-13(16(11)12)8-10-19-14/h5-6,12H,2-4,7-10H2,1H3,(H,17,18)/t12-/m0/s1

InChI 密鑰

YLXDSYKOBKBWJQ-LBPRGKRZSA-N

基因資訊

尋找類似的產品? 前往 產品比較指南

生化/生理作用

拉米替隆是 MT1/MT2 褪黑激素受体的一种细胞渗透性、有效和选择性激动剂,具有促进睡眠的特性。它不与 GABA 受体复合物结合。拉米替隆是最近被批准用于治疗失眠的褪黑激素的类似物。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Thomas Roth et al.
Sleep, 28(3), 303-307 (2005-09-22)
Evaluate the efficacy of ramelteon, an MT/1MT2-receptor agonist, for the treatment of transient insomnia in healthy adults. Randomized, double-blind, placebo-controlled design using a model of transient insomnia related to sleeping in a novel environment. Fourteen sleep research centers. Healthy adults
Wei Zhou et al.
PloS one, 11(11), e0166442-e0166442 (2016-11-11)
"Perioceutics" including antimicrobial therapy and host modulatory therapy has emerged as a vital adjunctive treatment of periodontal disease. Melatonin level was significantly reduced in patients with periodontal diseases suggesting melatonin could be applied as a potential "perioceutics" treatment of periodontal
Yasushi Yabuki et al.
Molecular neurobiology, 55(4), 3577-3591 (2017-05-19)
We previously reported that fatty acid-binding protein 3 (FABP3) knockout (Fabp3
Chuo Li et al.
Bioengineered, 12(1), 4868-4877 (2021-08-05)
Parkinson's disease (PD) is a common neurodegenerative disease with global health and economic impact. 1-methyl-4-phenylpyridinium (MPP+)-induced mitochondrial dysfunction and oxidative stress are reported to participate in the pathological mechanism of PD. Ramelteon is a novel oral hypnotic agent that has

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