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Key Documents

SML1807

Sigma-Aldrich

SB-258719

≥98% (HPLC)

同義詞:

N,3-二甲基-N-[((1R)-1-甲基-3-(4-甲基-1-哌啶基)丙基]苯磺酰胺, SB 258719

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About This Item

經驗公式(希爾表示法):
C18H30N2O2S
CAS號碼:
分子量::
338.51
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

oil

顏色

off-white to brown

儲存溫度

2-8°C

SMILES 字串

CC1=CC=CC(S(N(C)[C@H](C)CCN2CCC(C)CC2)(=O)=O)=C1

InChI

1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3

InChI 密鑰

AGVNHDNTFYHZNL-UHFFFAOYSA-N

生化/生理作用

SB-258719 是一种选择性和有效的 5-HT7 拮抗剂。SB-258719 逆转了 5-CT 对小鼠的低温作用。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Xin Zhao et al.
Scientific reports, 5, 9043-9043 (2015-03-13)
Fisetin, a natural flavonoid, has been shown in our previous studies to exert antidepressant-like effect. As antidepressant drugs are clinically used to treat chronic neuropathic pain, this work aimed to investigate the potential antinociceptive efficacies of fisetin against neuropathic pain
D R Thomas et al.
British journal of pharmacology, 124(6), 1300-1306 (1998-08-28)
1. The functional profile of the long form of the human cloned 5-HT7 receptor (designated h5-HT7(a)) was investigated using a number of 5-HT receptor agonists and antagonists and compared with its binding profile. Receptor function was measured using adenylyl cyclase
Sarwat Fatima et al.
Molecular oncology, 10(2), 195-212 (2015-10-18)
5-Hydroxytryptamine (5-HT), a neurotransmitter and vasoactive factor, has been reported to promote proliferation of serum-deprived hepatocellular carcinoma (HCC) cells but the detailed intracellular mechanism is unknown. As Wnt/β-catenin signalling is highly dysregulated in a majority of HCC, this study explored

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