暫時無法取得訂價和供貨情況
推薦產品
品質等級
形狀
powder
抗生素活性譜
Gram-positive bacteria
作用方式
protein synthesis | interferes
儲存溫度
−20°C
SMILES 字串
FC1(Oc2c(ccc(c2)NC(=O)Nc3cc(c(cc3)Cl)C(F)(F)F)O1)F
InChI
1S/C15H8ClF5N2O3/c16-10-3-1-7(5-9(10)14(17,18)19)22-13(24)23-8-2-4-11-12(6-8)26-15(20,21)25-11/h1-6H,(H2,22,23,24)
InChI 密鑰
SHPYXCLUNMOJOB-UHFFFAOYSA-N
一般說明
生化／生理作用
PK150 is a potent antibiotic, which displays strong antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) at a sub-micromolar level.[2] It elicits anti-biofilm activity and eliminates persisters.[2] PK150 also shows oral bioavailability, and in vivo efficacy in mouse model.[2]
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
從最近期的版本中選擇一個：
Philipp Le et al.
Nature chemistry, 12(2), 145-158 (2019-12-18)
New drugs are desperately needed to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report screening commercial kinase inhibitors for antibacterial activity and found the anticancer drug sorafenib as major hit that effectively kills MRSA strains. Varying the key structural
Robert Macsics et al.
Applied and environmental microbiology, 86(16) (2020-06-07)
Triclocarban (TCC), a formerly used disinfectant, kills bacteria via an unknown mechanism of action. A structural hallmark is its N,N'-diaryl urea motif, which is also present in other antibiotics, including the recently reported small molecule PK150. We show here that
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