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Key Documents

SAB4300531

Sigma-Aldrich

抗 BCL2L11 (Ab-69) 兔抗

affinity isolated antibody

同義詞:

Anti-BAM antibody produced in rabbit, Anti-BCL2-like 11 (apoptosis facilitator) antibody produced in rabbit, Anti-BIM antibody produced in rabbit, Anti-BIM-alpha6 antibody produced in rabbit, Anti-BIM-beta6 antibody produced in rabbit

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

共軛

unconjugated

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

分子量

~23 kDa

物種活性

rat, human, mouse

濃度

1 mg/mL

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000

同型

IgG

免疫原序列

(P-A-S-P-G)

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... BCL2L11(10018)

一般說明

Bcl-2(B-cell lymphoma 2)-like protein 11 (BCL2L11) also known as Bcl-2 interacting mediator of cell death (BIM), belongs to BH3-only death activator family. In human chromosome, the gene BCL2L11 is localized on 2q13.

免疫原

Peptide sequence around aa. 67-71 (P-A-S-P-G), according to the protein BCL2L11.

生化/生理作用

Bcl-2-like protein 11 (BCL2L11) is a key factor for determining the cell fate in the absence of cytokines. BCL2L11 is a pro-apoptotic protein, which initiates intrinsic apoptotic pathway and causes apoptosis. BIM initiates apoptosis upon upregulation by tyrosine kinase inhibitors (TKI) and binds to pro-survival Bcl2 family through its SH3 domain. BIM is a key factor to evaluate cancer therapy outcomes. Downregulation of BCL2L11 by either polymorphism or promoter hypermethylation, results in survival of chronic myeloid leukaemia cells and also provides drug resistance. BCL2L11 is associated with lymphomagenesis. Upregulation of MicroRNA (miR-24) suppresses BCL2L11 expression in gastrointestinal tumour, promotes cell proliferation and invasion.

特點和優勢

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

標靶描述

Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.

外觀

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer
Zhang H, et al
Protein & cell, 7(2), 141-151 (2016)
Molecular pathogenesis of mantle cell lymphoma
Jares P, et al.
The Journal of Clinical Investigation, 122(10), 3416-3423 (2012)
DNA hypermethylation promotes the low expression of pro-apoptotic BCL2L11 associated with BCR-ABL1 fusion gene of chronic myeloid leukaemia
Leo E, et al.
British Journal of Haematology, 159(3), 373-376 (2012)
PRRC2A and BCL2L11 gene variants influence risk of non-Hodgkin lymphoma: results from the InterLymph consortium
Nieters A, et al.
Blood, 120, 4645-4648 (2012)
A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer
Soh SX, et al.
Oncotarget, 8(25), 41474-41486 (2017)

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