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SAB3300047

Sigma-Aldrich

Monoclonal Anti-TUBB3 antibody produced in mouse

clone 5H2, purified immunoglobulin, buffered aqueous glycerol solution

同義詞:

Anti-β-4, Anti-MC1R, Anti-TUBB4

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About This Item

分類程式碼代碼:
12352203

生物源

mouse

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

5H2, monoclonal

形狀

buffered aqueous glycerol solution

分子量

antigen 50.3 kDa

物種活性

human

技術

western blot: suitable

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

基因資訊

human ... TUBB3(10381)

免疫原

Recombinant protein expressed in E. coli corresponding to amino acids 1-150 of human TUBB3

標靶描述

Tubulin is the major building block of microtubules. This intracellular cylindrical filamentous structure is present in almost all eukaryotic cells. Microtubules function as structural and mobile elements in mitosis, intracellular transport, flagellar movement, and the cytoskeleton. Except in the simplest eukaryotes, tubulin exists in all cells as a mixture of similar, but not identical, sets of alpha and beta tubulin polypeptides. Within either set of polypeptides, individual subunits diverge from each other (both within and across species) at less than 10% of the amino acid positions. The most extreme diversity is localized to the 15 residues of the carboxy terminal. For β-tubulin five evolutionarily conserved isotype clones have been identified. These are almost totally conserved in the subunits utilized in the same cell types of different species, with the exception of the hematopoietic β-tubulin which is the most highly divergent in sequence and is not conserved between species. Research has been centered around the hypothesis that these beta tubulin isotypes contribute to unique functional properties. It has been reported that the different isotypes of tubulin differ from each other in their ability to polymerize into microtubules.

外觀

Solution in phosphate buffered saline containing 1% bovine serum albumin, 50% glycerol, and 0.02% sodium azide.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Emily Palmero et al.
Scientific reports, 6, 39394-39394 (2016-12-20)
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Jessica E M Dunleavy et al.
Development (Cambridge, England), 148(24) (2021-11-26)
Katanin microtubule-severing enzymes are crucial executers of microtubule regulation. Here, we have created an allelic loss-of-function series of the katanin regulatory B-subunit KATNB1 in mice. We reveal that KATNB1 is the master regulator of all katanin enzymatic A-subunits during mammalian

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

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