SAB1100176

Anti-GUCY2C (981-995) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 同義詞: Anti-GUC2C, Anti-Guanylate cyclase 2C (heat stable enterotoxin receptor), Anti-STAR
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: IgG fraction of antiserum
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~123 kDa
• 物種活性: human
• 技術: western blot: 1:500-1:2,000
• UniProt登錄號: P25092
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... GUCY2C(2984)

描述

一般說明

The guanylate cyclase 2C (GUCY2C) gene is mapped to human chromosome 12p12. The gene codes for a transmembrane receptor guanylate cyclase C (GC-C) and is expressed in intestine.

免疫原

synthetic peptide corresponding to amino acids 981-995 of human GUCY2C

應用

Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

生化／生理作用

Guanylate cyclase 2C (GUCY2C) converts guanosine-5′-triphosphate (GTP) to cyclic guanosine monophosphate (cGMP), upon binding of its ligand guanylin and uroguanylin, which are paracrine hormones. GUCY2C functions as a tumor suppressor and hinders intestinal tumorigenesis by inhibiting the protein kinase B/AKT signaling pathway. Transmembrane receptor guanylate cyclase C (GC-C) regulates the secretion of chloride. Alteration in the gene expression leads to congenital sodium diarrhoea (CSD).

外觀

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable