推薦產品
化驗
≥98% (HPLC)
形狀
solid
儲存條件
protect from light
顏色
yellow
溶解度
DMSO: >10 mg/mL
H2O: <2 mg/mL
儲存溫度
−20°C
SMILES 字串
Brc1ccc(OCc2ccccc2Br)c(c1)\C=C3\SC(=S)NC3=O
InChI
1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+
InChI 密鑰
HXNBAOLVPAWYLT-OVCLIPMQSA-N
應用
PRL-3抑制剂I已被用作再生肝磷酸酶-3 (PRL-3)的抑制剂：
- 检测其对经典霍奇金淋巴瘤细胞存活的影响
- 用于人脐静脉内皮细胞成管实验
- 用于检测其对神经嵴细胞迁移的影响
生化／生理作用
PRL-3抑制剂I是一种罗丹宁衍生物，其对再生肝3磷酸酶（PRL-3）的IC50值为0.9 μM，PRL-3是一种非经典的蛋白质酪氨酸磷酸酶，最近被证明与癌症转移有关。 PRL-3抑制剂I在基于细胞的测定中可降低B16F10黑色素瘤细胞的侵袭性。
特點和優勢
《受体分类和信号转导》手册的 磷蛋白磷酸酶（酪氨酸） 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
VEGF promotes the transcription of the human PRL-3 gene in HUVEC through transcription factor MEF2C.
Jianliang Xu et al.
PloS one, 6(11), e27165-e27165 (2011-11-11)
Phosphatase of regenerating liver 3 (PRL-3) is known to be overexpressed in many tumors, and its transcript level is high in the vasculature and endothelial cells of malignant tumor tissue. However, the mechanism(s) underlying its enhanced expression and its function
Magnus Aassved Hjort et al.
Experimental hematology & oncology, 7, 8-8 (2018-04-14)
Phosphatase of regenerating liver-3 (PRL-3) is implicated in oncogenesis of hematological and solid cancers. PRL-3 expression increases metastatic potential, invasiveness and is associated with poor prognosis. With this study, we aimed to show a possible oncogenic role of PRL-3 in
Ying-Qian Lu et al.
Stem cell research, 34, 101354-101354 (2019-01-06)
The human iPS cell line, hiPS-SPG76 (FJMUi001-A), derived from skin fibroblasts from a 42-year-old male hereditary spastic paraplegia patient carrying compound heterozygous p.P498L (c.1493C > T) and p.R618W (c.1852C > T) mutations in the CAPN1 gene, was generated by non-integrative reprogramming vectors encoding OCT3/4
Jin Hee Ahn et al.
Bioorganic & medicinal chemistry letters, 16(11), 2996-2999 (2006-03-15)
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most active in this series exhibiting an IC50 value of 0.9 microM in
E G Garcia et al.
Leukemia, 35(3), 679-690 (2020-07-02)
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes and is largely driven by the NOTCH/MYC pathway. Yet, additional oncogenic drivers are required for transformation. Here, we identify protein tyrosine phosphatase type 4 A3 (PRL3) as a collaborating
文章
Protein tyrosine phosphatases' catalytic mechanism involves transient phosphorylation.
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