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文件

M2389

Sigma-Aldrich

N6-甲基-2′-脱氧腺苷

同義詞:

6mdA, N6-Me-dAdo, m6dA

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About This Item

經驗公式(希爾表示法):
C11H15N5O3
CAS號碼:
分子量::
265.27
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51

化驗

≥98% (TLC)

品質等級

形狀

powder

溶解度

acetic acid: 49.00-51.00 mg/mL, clear, colorless

儲存溫度

−20°C

SMILES 字串

CNc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3

InChI

1S/C11H15N5O3/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(18)7(3-17)19-8/h4-8,17-18H,2-3H2,1H3,(H,12,13,14)/t6-,7+,8+/m0/s1

InChI 密鑰

DYSDOYRQWBDGQQ-XLPZGREQSA-N

應用

N6-甲基-2′-脱氧腺苷已用作标准品,结合超高效液相色谱法和三重四极杆质谱法(UHPLC-QQQ-MS/MS)来测定基因组DNA中的修饰碱基水平。它还用于研究其促进红系祖细胞增殖潜力。

生化/生理作用

N6-甲基-2′-脱氧腺苷(N6-Me-dAdo)是N6-甲基2′-脱氧腺苷3′,5′-二磷酸盐(N6MABP)的前体,后者是P2Y受体的一种竞争性和选择性抑制剂。它位于转录起始位点,在莱茵衣藻的增强基因表达中起作用。N6-Me-dAdo可增强内部转座因子,在果蝇的发育过程中处于较高水平。它在原核生物和原生生物中参与基因转录、DNA修复和复制的调节。与基因体互补的N6-Me-dAdo可能诱导人细胞的基因表达。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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