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Merck
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文件

M2017

Sigma-Aldrich

马吲哚

≥98% (TLC), powder

同義詞:

5-(4-Chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol

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About This Item

經驗公式（希爾表示法）:
C16H13ClN2O
CAS號碼:
22232-71-9
分子量：:
284.74
EC號碼:
244-857-0
MDL號碼:
MFCD00864480
分類程式碼代碼:
12352200
PubChem物質ID:
24896596
NACRES:
NA.77

化驗

≥98% (TLC)

形狀

powder

藥物控制

USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

顏色

white

溶解度

DMSO: 10 mg/mL

起源

Wyeth

SMILES 字串

OC1(C2=CC=C(Cl)C=C2)C3=CC=CC=C3C4=NCCN14

InChI

1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2

InChI 密鑰

ZPXSCAKFGYXMGA-UHFFFAOYSA-N

基因資訊

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)
rat ... Htr1a(24473) , Htr2a(29595) , Slc6a3(24898) , Slc6a4(25553)

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生化／生理作用

Anorectic agent; inhibits the dopamine, norepinephrine and serotonin transporters with Kis of 27.6 nM, 3.2 nM, and 153 nM, respectively.

特點和優勢

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300,H311 + H331

危險分類

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

分析證明 (COA)

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Johannes Backs et al.
Cardiovascular research, 67(2), 283-290 (2005-07-12)
Endothelin-1 (ET-1) potentiates norepinephrine (NE)-induced contractile responses. An impairment of cardiac NE re-uptake by the neuronal NE transporter (NET) contributes to an increased NE net release in failing hearts. We hypothesized that both phenomena are caused by ET-1-mediated inhibition of
W Michael Caudle et al.
Neurotoxicology, 26(4), 721-728 (2005-08-23)
Although banned in the 1970s, significant levels of the organochlorine pesticide heptachlor are still present in the environment raising concern over potential human exposure. In particular, organochlorine pesticides have been linked to an increased risk of Parkinson's disease. Studies from
Mari Gabrielsen et al.
European journal of medicinal chemistry, 47(1), 24-37 (2011-11-11)
The two main groups of antidepressant drugs, the tricyclic antidepressants (TCAs) and the selective serotonin reuptake inhibitors (SSRIs), as well as several other compounds, act by inhibiting the serotonin transporter (SERT). However, the binding mode and molecular mechanism of inhibition
Abid Oueslati et al.
The European journal of neuroscience, 22(11), 2765-2774 (2005-12-06)
This study examined the cellular correlates of the akinetic deficits produced in Wistar rats by discrete bilateral 6-hydroxydopamine (6-OHDA) striatal infusions in the dorsolateral striatum, mimicking the preferential denervation of the motor striatal territory in early symptomatic stage of Parkinson's
Kasper Severinsen et al.
Molecular pharmacology, 85(2), 208-217 (2013-11-12)
Mazindol has been explored as a possible agent in cocaine addiction pharmacotherapy. The tetracyclic compound inhibits both the dopamine transporter and the serotonin transporter, and simple chemical modifications considerably alter target selectivity. Mazindol, therefore, is an attractive scaffold for both
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