K0765

Anti-Potassium Channel K_V11.2 (erg2) 兔抗

affinity isolated antibody, lyophilized powder

• 同義詞: Anti-KCNH6, Anti-ether-a-go-go-related channel 2
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: lyophilized powder
• 物種活性: rat
• 技術: immunohistochemistry: suitable; western blot: 1:200 using rat brain and rat cortex lysates
• UniProt登錄號: O54853
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: rat ... Kcnh6(116745)

描述

一般說明

The gene Kcnh6 (potassium voltage-gated channel subfamily H member 6), also referred to as erg2, encodes a subunit of ether-à-go-go related (erg) K⁺ channels. The erg K+ channels are part of the EAG (ether-à-go-go) family of voltage-gated K⁺ channels. The encoded protein is found to be expressed in the rat retina. The three isoforms erg1, erg2, and erg3 are found to be expressed in the brain. They are strongly expressed in the olfactory bulb.

免疫原

peptide TLNFVEFNLEKHRS(C), corresponding to residues 185- 198 of human Kv11.2 located in N-terminal part of human Kv11.2.

生化／生理作用

The gene Kcnh6 (potassium voltage-gated channel subfamily H member 6) encodes a voltage gated K⁺ channel that modulates the membrane potential in its rested and activated state. It may participate in the tweaking of the presynaptic membrane potential, thereby regulating neurotransmitter release.

標靶描述

Potassium Channel K_V11.2 (erg2) encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. K_v11.2 produces currents characterized by strong inward rectification with slow activation and very rapid inactivation kinetics, which closely resemble those produced by the much studied channel K_v11.1. The expression of K_v11.2 seems to be limited to the brain and the pituitary gland.

外觀

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% BSA and 0.025% sodium azide.

重構

Reconstitute with 50 μL or 200 μL deionized water, depending on package size. Further dilutions should be made using a carrier protein such as BSA (1-3%).

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids