I1288

IL28β human

recombinant, expressed in HEK 293 cells, suitable for cell culture

• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 重組細胞: expressed in HEK 293 cells
• 化驗: ≥95% (SDS-PAGE)
• 形狀: lyophilized powder
• 效力: ≤1 ng/mL EC₅₀ (measured in a viral resistance assay)
• 技術: cell culture | mammalian: suitable
• 雜質: Endotoxin, tested
• 儲存溫度: −20°C

描述

一般說明

Recombinant human IL28β is expressed in HEK 293 cells with a calculated molecular mass of ~20 kDa. This protein is manufactured in human cells using an all-human production system, with full chemically defined ingredients and with no serum. The human cells expression system allows human-like folding, and often supports better stability of the protein in culture. The protein is produced with no artificial tags.

生化／生理作用

IL28β is a newly-discovered type III interferon, with antiviral, antiproliferative, and immunomodulatory functions. Type III IFNs share homology with IL-10 and the IL-10R2 receptor subunit, leading to the speculation that these cytokines might be evolutionarily related. It was recently found that polymorphisms in IFN-lambda-4 (another type III interferon) are associated with circulating IL28β, and higher plasma IL28β are associated with higher production of antibodies to HBV surface antigen. IL28β is associated with the extent of lupus activity, in particular with active serosal and cutaneous disease. Combined treatment with IL28β and sorafenib (a small molecule multikinase inhibitor) facilitates a synergistic effect on suppressing hepatocellular carcinoma cancer growth and promoting cell apoptosis in vitro and in vivo.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable