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Merck
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文件

E001

Sigma-Aldrich

β-咔啉-3-羧酸乙酯

solid

同義詞:

β-CCE, 9H-吡啶并[3,4-b]吲哚-3-羧酸乙酯

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About This Item

經驗公式(希爾表示法):
C14H12N2O2
CAS號碼:
分子量::
240.26
MDL號碼:
分類程式碼代碼:
12352103

形狀

solid

mp

228-230 °C (lit.)

溶解度

ethanol: 3.5 mg/mL (warm)
DMSO: soluble

SMILES 字串

CCOC(=O)c1cc2c(cn1)[nH]c3ccccc23

InChI

1S/C14H12N2O2/c1-2-18-14(17)12-7-10-9-5-3-4-6-11(9)16-13(10)8-15-12/h3-8,16H,2H2,1H3

InChI 密鑰

KOVRZNUMIKACTB-UHFFFAOYSA-N

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生化/生理作用

苯二氮卓反向激动剂,可与大脑中苯二氮卓受体的内源性配体密切相关。

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訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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P Skolnick et al.
Psychopathology, 17 Suppl 1, 25-36 (1984-01-01)
The ethyl ester of beta-carboline-3-carboxylic acid (beta-CCE) has a high affinity for benzodiazepine receptors and can antagonize some of the pharmacologic actions of benzodiazepines in rodents. Administration of beta-CCE (2.5 mg/kg) to chair-adapted, male rhesus monkeys (7-9 kg) elicited a
P J Cowen et al.
Nature, 290(5801), 54-55 (1981-03-05)
The mammalian central nervous system possesses specific high-affinity binding sites for the benzodiazepines and considerable evidence suggests that these binding sites are the pharmacological receptors through which these compounds act. Recently, ethyl beta-carboline-3-carboxylate (beta-CCE) has been identified in both human
C Braestrup et al.
Science (New York, N.Y.), 216(4551), 1241-1243 (1982-06-11)
The gamma-aminobutyric acid (GABA)-benzodiazepine receptor complex, which is composed of distinct proteins embedded in the neuronal plasma membrane, is important for several effects of benzodiazepines, including protection afforded against convulsions. During structural modification of ethyl beta-carboline-3-carboxylate an agent was discovered

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