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D0815

Sigma-Aldrich

2-[4-(Dimethylamino)styryl]-1-ethylpyridinium iodide

≥99% purity (HPLC), solid

同義詞:

DASPEI

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About This Item

經驗公式(希爾表示法):
C17H21IN2
CAS號碼:
分子量::
380.27
Beilstein:
3783243
EC號碼:
MDL號碼:
分類程式碼代碼:
12171500
PubChem物質ID:
NACRES:
NA.47

product name

2-[4-(Dimethylamino)styryl]-1-ethylpyridinium iodide, ≥99% (HPLC), solid

品質等級

化驗

≥99% (HPLC)

形狀

solid

顏色

red

mp

267 °C (dec.) (lit.)

溶解度

DMSO: 0.5 mg/mL
methanol: soluble

εmax

36.0-41.0 at 457-463 nm in methanol

應用

diagnostic assay manufacturing
hematology
histology

儲存溫度

2-8°C

SMILES 字串

[I-].CC[n+]1ccccc1\C=C\c2ccc(cc2)N(C)C

InChI

1S/C17H21N2.HI/c1-4-19-14-6-5-7-17(19)13-10-15-8-11-16(12-9-15)18(2)3;/h5-14H,4H2,1-3H3;1H/q+1;/p-1

InChI 密鑰

AMAXNNVXIBDEMV-UHFFFAOYSA-M

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應用

2-[4-(Dimethylamino)styryl]-1-ethylpyridinium iodide (DASPEI) has been used for the labelling of hair cells in larval zebrafish.

生化/生理作用

2-[4-(Dimethylamino)styryl]-1-ethylpyridinium iodide (DASPEI) accumulates in the mitochondria and has a large fluorescence Stokes shift. It is also used for the relative measurements of mitochondrial membrane potential.
Suitable as a mitochondrial stain in live cells.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin.
Vlasits AL, et al.
Hearing Research, 294, 153-165 (2012)
Ru Zhang et al.
Biomolecules, 10(10) (2020-10-22)
Cochlear hair cells in human beings cannot regenerate after loss; however, those in fish and other lower species can. Recently, the role of inflammation in hair cell regeneration has been attracting the attention of scientists. In the present study, we
Marina Yoffe et al.
Journal of experimental zoology. Part B, Molecular and developmental evolution, 334(7-8), 511-517 (2020-05-22)
The lateral line is the primary modality fish use to create a hydrodynamic image of their environment. These images contribute to a variety of behaviors, from rheotaxis to escape responses. Here we discern the contributions of visual and lateral line
Development of a no-wash assay for mitochondrial membrane potential using the styryl dye DASPEI.
Jensen KH and Rekling JC
Journal of Biomolecular Screening, 15, 1071-1081 (2010)
W Armand Guiguemde et al.
Nature, 465(7296), 311-315 (2010-05-21)
Malaria caused by Plasmodium falciparum is a disease that is responsible for 880,000 deaths per year worldwide. Vaccine development has proved difficult and resistance has emerged for most antimalarial drugs. To discover new antimalarial chemotypes, we have used a phenotypic

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