vial of 0.1 mL concentrate (477R-14) vial of 0.1 mL concentrate Research Use Only (477R-14-RUO) vial of 0.5 mL concentrate (477R-15) vial of 1.0 mL concentrate (477R-16) vial of 1.0 mL concentrate Research Use Only (477R-16-RUO) vial of 1.0 mL pre-dilute Research Use Only (477R-17-RUO) vial of 1.0 mL pre-dilute ready-to-use (477R-17) vial of 7.0 mL pre-dilute ready-to-use (477R-18) vial of 7.0 mL pre-dilute ready-to-use Research Use Only (477R-18-RUO)
Melanoma-associated antigen C2 (MAGEC2), encoded by the testis cancer gene CT10, belongs to a family of proteins that bind E3 RING ubiquitin ligases via a common MAGE homology domain.1-3 The MAGE-RING complexes that are formed enhance the activity of the ubiquitin ligase binding partners. In vitro studies suggest that MAGEC2, which binds to TRIM28, is involved in tumorigenesis through the increased degradation of p53.4 In germ cell tumors, aberrant expression of MAGEC2 is exhibited in seminomas, but is absent in yolk sac tumor and embryonal carcinoma.5-7
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United States - IVD Canada - RUO European Union - IVD Japan - RUO
外觀
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
Primary mediastinal seminomas are unusual tumors that can present in a pure form or as part of a mixed germ cell tumor. Contrary to testicular seminomas, little is known about the expression of novel immunohistochemical markers in mediastinal seminomas. This
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 24(6), 829-835 (2011-07-23)
Melanoma-associated gene C2 (MAGEC2) is a recently identified cancer testis antigen expressed in normal testicular and placental tissue. It has been detected in some human carcinomas, but its expression in primary testicular germ cell tumors is unknown. Immunohistochemistry was used
Human reproduction (Oxford, England), 26(12), 3232-3243 (2011-10-22)
Cancer/testis (CT) antigens are cancer antigens normally expressed in adult testicular germ cells. The expression of chromosome X-encoded CT antigens (CT-X antigens) in human fetal gonads and in testicular seminomas was examined. The expression of 10 CT-X antigens (MAGEA, NY-ESO-1
Journal of molecular biology, 429(8), 1114-1142 (2017-03-17)
Melanoma antigen (MAGE) genes are conserved in all eukaryotes and encode for proteins sharing a common MAGE homology domain. Although only a single MAGE gene exists in lower eukaryotes, the MAGE family rapidly expanded in eutherians and consists of more
CT10/MAGE-C2 is a recently identified antigen that, typically of cancer/testis (CT) antigens, can be found in various malignant tumors and in normal adult testis. As with many other CT antigens, our knowledge is based mainly on mRNA expression data. In
