MABC607

Anti-MTSS1 Antibody, clone 15C3.2

clone 15C3.2, from mouse

• 同義詞: Metastasis suppressor protein 1, Metastasis suppressor YGL-1, Missing in metastasis protein, MTSS1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.43

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: 15C3.2, monoclonal
• 物種活性: monkey, human
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同型: IgG2aκ
• NCBI登錄號: NP_055566
• UniProt登錄號: O43312
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... MTSS1(9788)

描述

一般說明

Metastasis suppressor protein 1 (UniProt O43312; also known as Metastasis suppressor YGL-1, Missing in metastasis protein) is encoded by the MTSS1 (also known as KIAA0429, MIM) gene (Gene ID 9788) in human. MTSS1 is a scaffold protein that regulates cytoskeletal dynamics and actin polymerization. MTSS1 is also reported to bind Gli proteins or the Gli-Sufu complex and potentiate the transcription of effector genes of the sonic hedgehog signaling pathway. MTSS1 is down-regulated in many metastatic cancer cells compared with their non-metastatic counterparts. MTSS1 expression is shown to be inversely correlated with the prognosis of solid carcinomas of the breast, liver, and bladder.

特異性

This clone is expected to react with all 4 spliced isoforms of human MTSS1.

免疫原

Epitope: C-terminal

GST-tagged recombinant protein corresponding to the C-terminal of human MTSS1.

應用

Detect MTSS1 using this mouse monoclonal Anti-MTSS1 Antibody, clone 15C3.2, Cat. No. MABC607, validated for use in Western Blotting and Immunohistochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected MTSS1 in human colon and human spleen tissues.

Research Category
Apoptosis & Cancer

Research Sub Category
Apoptosis - Additional

品質

Evaluated by Western Blotting in COS-1 cell lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected MTSS1 in 10 µg of COS-1 cell lysate.

標靶描述

~82 kDa observed

外觀

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable