推薦產品
生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
mouse, rat
物種活性（以同源性預測）
human (immunogen homology)
技術
immunohistochemistry: suitable
western blot: suitable
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... RAPGEF4(11069)
一般說明
Exchange factor directly activated by cAMP 2 (EPAC2), also known as Rap guanine nuclear exchange factor 4 (RAPGEF4) and cAMP-regulated guanine nucleotide exchange factor II (cAMPGEF-II), belong to a family of cyclic adenosine monophosphate (cAMP) binding proteins that act as a guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B, and RAP2A small GTPases that are activated through cAMP binding. EPAC2 signaling plays a role in numerous cellular processes such as integrin-mediated cell adhesion, muscle contraction, learning and memory, cell proliferation, exocytosis and inflammation. EPAC2 has been found to induce synapse remodeling and depression, with mutations in its gene being found in patients with autism. EPAC2 is predominantly expressed in brain and adrenal gland.
免疫原
KLH-conjugated linear peptide corresponding to human EPAC2.
應用
Anti-EPAC2 Antibody is a highly specific rabbit polyclonal antibody, that targets Epac & has been tested in western blotting & IHC.
Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected EPAC2 in mouse liver tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Developmental Neuroscience
Developmental Neuroscience
品質
Evaluated by Western Blotting/Peptide Inhibition Assay in rat liver tissue lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected EPAC2 in 15 µg of rat liver tissue lysate.
Western Blotting/Peptide Inhibition Assay Analysis: 1 µg/mL of this antibody detected EPAC2 in 15 µg of rat liver tissue lysate.
標靶描述
~129 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 3 isoforms at ~79 kDa, ~100 kDa, and ~116 kDa
外觀
Antigen Affinity Purified
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
Rat liver tissue lysate
Rat liver tissue lysate
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Michel Rasmussen et al.
Journal of neurochemistry, 157(6), 2173-2186 (2020-11-25)
The hereditary disease Retinitis pigmentosa results in severe vision loss due to photoreceptor degeneration by unclear mechanisms. In several disease models, the second messenger cGMP accumulates in the degenerating photoreceptors, where it may over-activate specific cGMP-interacting proteins, like cGMP-dependent protein
Michel Rasmussen et al.
International journal of molecular sciences, 23(9) (2022-05-15)
The disease retinitis pigmentosa (RP) leads to photoreceptor degeneration by a yet undefined mechanism(s). In several RP mouse models (i.e., rd mice), a high cyclic GMP (cGMP) level within photoreceptors is detected, suggesting that cGMP plays a role in degeneration.
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