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Merck
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Key Documents

344085

Sigma-Aldrich

Folimycin, Streptomyces sp.

A highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM).

同義詞:

Folimycin, Streptomyces sp., Concanamycin A

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About This Item

經驗公式（希爾表示法）:
C46H75NO14
CAS號碼:
80890-47-7
分子量：:
866.09
MDL號碼:
MFCD00210037
分類程式碼代碼:
12352200

品質等級

100

化驗

≥90% (HPLC)

形狀

lyophilized solid

製造商／商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

溶解度

DMSO: soluble

運輸包裝

ambient

儲存溫度

−20°C

InChI

1S/C46H75NO14/c1-13-16-34-28(7)37(58-38-22-33(48)43(31(10)57-38)60-45(47)53)23-46(54,61-34)30(9)41(51)29(8)42-35(55-11)18-15-17-24(3)19-26(5)39(49)32(14-2)40(50)27(6)20-25(4)21-36(56-12)44(52)59-42/h13,15-18,20-21,26-35,37-43,48-51,54H,14,19,22-23H2,1-12H3,(H2,47,53)/b16-13+,18-15+,24-17+,25-20+,36-21-/t26-,27-,28-,29+,30+,31-,32+,33-,34-,35+,37-,38+,39+,40-,41-,42-,43-,46-/m1/s1

InChI 密鑰

DJZCTUVALDDONK-HQMSUKCRSA-N

一般說明

A highly sensitive and specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 20 pM). Inhibits acidification of organelles, such as lysosomes and the Golgi apparatus. Also blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. Useful for studies of intracellular protein translocation. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay.

生化／生理作用

Cell permeable: no
Primary Target
Vacuolar-type H+-ATPase
Product does not compete with ATP.
Reversible: no
Target Ki: 20 pM against vacuolar-type H+-ATPase

警告

Toxicity: Highly Toxic (H)

準備報告

Further dilute with aqueous buffers just prior to use.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Kane, M.D., et al. 1999. J. Neurochem.72, 1939.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun.212, 255.
Muroi, M., et al. 1994. Biosci. Biotech. Biochem.58, 425.
Drose, S., et al. 1993. Biochemistry32, 3902.
Muroi, M., et al. 1993. Biochem. Biophys. Res. Commun.193, 999.
Muroi, M., et al. 1993. Cell Struct. Funct.18, 139.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險分類

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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Peter Göttle et al.
Frontiers in cellular neuroscience, 15, 777542-777542 (2021-12-11)
Myelin repair in the adult central nervous system (CNS) is driven by successful differentiation of resident oligodendroglial precursor cells (OPCs) and thus constitutes a neurodegenerative process capable to compensate for functional deficits upon loss of oligodendrocytes and myelin sheaths as
Michael J Rigby et al.
Communications biology, 4(1), 454-454 (2021-04-14)
Nε-lysine acetylation in the ER lumen is a recently discovered quality control mechanism that ensures proteostasis within the secretory pathway. The acetyltransferase reaction is carried out by two type-II membrane proteins, ATase1/NAT8B and ATase2/NAT8. Prior studies have shown that reducing
Keiji Ibata et al.
Neuron, 102(6), 1184-1198 (2019-05-11)
Synapse formation is achieved by various synaptic organizers. Although this process is highly regulated by neuronal activity, the underlying molecular mechanisms remain largely unclear. Here we show that Cbln1, a synaptic organizer of the C1q family, is released from lysosomes
Jin Rui Liang et al.
Cell, 180(6), 1160-1177 (2020-03-12)
Selective autophagy of organelles is critical for cellular differentiation, homeostasis, and organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but is poorly understood beyond a few autophagosomal receptors and remodelers. By using an ER-phagy reporter and

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