跳轉至內容
Merck
全部照片(2)

Key Documents

220491

Sigma-Aldrich

Chk2 Inhibitor II

InSolution, ≥95%

同義詞:

InSolution Chk2 Inhibitor II, 2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide

登入查看組織和合約定價


About This Item

經驗公式(希爾表示法):
C20H14ClN3O2
CAS號碼:
分子量::
363.80
MDL號碼:
分類程式碼代碼:
12352200

品質等級

化驗

≥95% (HPLC)

形狀

liquid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

運輸包裝

ambient

儲存溫度

−20°C

InChI

1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)

InChI 密鑰

UXGJAOIJSROTTN-UHFFFAOYSA-N

一般說明

A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 M and 17 M, respectively) and only weakly affects the activities of a panel of 31 kinases (<25% inhibition at 10 M), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 M and 7.6 M, respectively. The solid form of this compound (Cat. No. 220486) is also available.

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

Supplied as a 25 mM (5 mg/550 µL) solution of Chk2 Inhibitor II (Cat. No. 220486) in DMSO.

重構

Following initial thaw, aliquot and freeze (-20°C).

其他說明

Arienti, K. L., et al. 2005. J. Med. Chem.48, 1873.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

188.6 °F - closed cup - (refers to pure substance)

閃點(°C)

87 °C - closed cup - (refers to pure substance)


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

已經擁有該產品?

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Ting-Yu Chen et al.
Cell death and differentiation, 28(6), 1865-1879 (2021-01-20)
The DNA-PK maintains cell survival when DNA damage occurs. In addition, aberrant activation of the DNA-PK induces centrosome amplification, suggesting additional roles for this kinase. Here, we showed that the DNA-PK-p53 cascade induced primary cilia formation (ciliogenesis), thus maintaining the

我們的科學家團隊在所有研究領域都有豐富的經驗,包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務