208923

CaMKII Inhibitor XII

• 同義詞: CaMKII Inhibitor XII, Ca ²⁺/Calmodulin-Dependent Protein Kinase II Inhibitor XII
• 經驗公式（希爾表示法）: C₂₉H₃₀ClN₅O₂S
• 分子量：: 548.10
• 分類程式碼代碼: 12352200
• NACRES: NA.28

屬性

• 化驗: ≥99% (HPLC)
• 品質等級: 100
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white
• 溶解度: DMSO: 100 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C

描述

一般說明

A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC₅₀ = 0.063 µM) with excellent selectivity over several kinases (IC₅₀ = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Asano, S., et al. 2010. Bioorg. Med. Chem. Lett.20, 6696.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable