生物源
rabbit
品質等級
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
rat, mouse
製造商／商標名
Upstate®
技術
western blot: suitable
同型
IgG
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
基因資訊
human ... NOTCH1(4851)
一般說明
The Notch protein family is a group of highly conserved proteins important in the determination of cell fate and maintenance of progenitors in many developmental systems. This family of proteins function both as membrane cell receptors and as transcription factors. Activation of Notch by cell-cell interactions causes a transcription inhibitory effect that enables inhibition of differentiation in some cells but not in others. As a consequence, some cells adopt a particular fate while other progenitors remain uncommitted. The Notch protein is important in cell fate during myogenesis, neurogenesis, oogenesis, and wing and eye development in Drosophila. In mammals, four Notch genes were identified (Notch 1-4) that are expressed in a wide variety of cells and play a crucial role in differentiation and development.
特異性
Notch1
免疫原
N-terminal GST fusion protein corresponding to residues 381-853 of rat Notch1
應用
Anti-Notch1 Antibody, extracellular domain is a high quality Rabbit Polyclonal Antibody for the detection of Notch1 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Used in mouse in the following publication: Gulino, R., et al, European Journal of Neuroscience, Vol. 31, pp. 1423–1434, 2010.
品質
Routinely evaluated by immunoblot on RIPA lysates from L/N17 rat Notch1 transfected fibroblast cells
標靶描述
260kDa
聯結
Replaces: 04-1046
外觀
Protein A chromatography
Format: Purified
Protein A purified immunoglobulin presented in 0.1M Tris-Glycine, 0.15M NaCl, and 0.05% Sodium Azide, pH 7.4
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
L/N17 transfected Notch1 cell lysate
L/N17 transfected Notch1 cell lysate
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10-13 - German Storage Class 10 to 13
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
Oswald, F, et al
Molecular and cellular biology, 18, 2077-2088 (1998)
C M Blaumueller et al.
Cell, 90(2), 281-291 (1997-07-25)
Previous models for signal transduction via the Notch pathway have depicted the full-length Notch receptor expressed at the cell surface. We present evidence demonstrating that the Notch receptor on the plasma membrane is cleaved. This cleavage is an evolutionarily conserved
G Struhl et al.
Cell, 93(4), 649-660 (1998-05-30)
The Drosophila Notch (N) gene encodes a conserved single-pass transmembrane receptor that transduces extracellular signals controlling cell fate. Here, we present evidence that the intracellular domain of Notch gains access to the nucleus in response to ligand, possibly through a
Notch signaling: direct or what?
Weinmaster, G
Current Opinion in Genetics & Development, 8, 436-442 (1998)
Bo Yan et al.
The Journal of biological chemistry, 277(33), 29760-29764 (2002-06-18)
Acid alpha-glucosidase (GAA) is a lysosomal enzyme that degrades glycogen. A deficiency of GAA is responsible for a recessively inherited myopathy and cardiomyopathy, glycogenosis type II. Previously, we identified an intronic repressor element in the GAA gene and demonstrated that
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