推薦產品
![VU0359595 (1R,2R)-N-([S]-1-{4-[5-bromo-2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxamide, powder](/deepweb/assets/sigmaaldrich/product/structures/317/424/cb93743d-b88f-4f55-8826-293f2730f20f/640/cb93743d-b88f-4f55-8826-293f2730f20f.png)
化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 1 mg (857370P-1mg)
製造商／商標名
Avanti Research™ - A Croda Brand 857370P
脂質類型
bioactive lipids
運輸包裝
dry ice
儲存溫度
−20°C
應用
VU0155056 has been used as a phospholipase D-1 (PLD1) inhibitor:
- to study its role in regulated exocytosis
- to test bacterial and human PLD enzymes for specificity of inhibition
- in neuro-2a (N2a) cell culture and survival assay
生化／生理作用
VU0155056 or N-(2-{4-[2-oxo-2,3-dihydro-1H-benzo(d)imidazol-1-yl]piperidin-1-yl ethyl)-2-naphthamide is a cell permeable phospholipase D (PLD) inhibitor. It inhibits both PLD1 and PLD2.
包裝
5 mL Amber Glass Screw Cap Vial (857370P-1mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Aditya Kulkarni et al.
Chemical biology & drug design, 84(3), 270-281 (2014-03-20)
Phospholipase D enzymes cleave lipid substrates to produce phosphatidic acid, an important precursor for many essential cellular molecules. Phospholipase D is a target to modulate cancer-cell invasiveness. This study reports synthesis of a new class of phospholipase D inhibitors based
Sarah McDavid et al.
PloS one, 9(10), e109203-e109203 (2014-10-03)
Butanol (C4H10OH) has been used both to dissect the molecular targets of alcohols/general anesthetics and to implicate phospholipase D (PLD) signaling in a variety of cellular functions including neurotransmitter and hormone exocytosis. Like other primary alcohols, 1-butanol is a substrate
Michael A Kennedy et al.
PLoS genetics, 7(2), e1001299-e1001299 (2011-02-25)
During Alzheimer's Disease, sustained exposure to amyloid-β₄₂ oligomers perturbs metabolism of ether-linked glycerophospholipids defined by a saturated 16 carbon chain at the sn-1 position. The intraneuronal accumulation of 1-O-hexadecyl-2-acetyl-sn-glycerophosphocholine (C16:0 PAF), but not its immediate precursor 1-O-hexadecyl-sn-glycerophosphocholine (C16:0 lyso-PAF), participates
Sarah A Scott et al.
Nature chemical biology, 5(2), 108-117 (2009-01-13)
Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid. Phosphatidic acid participates in both G protein-coupled receptor and receptor tyrosine kinase signal transduction networks. The lack of potent and isoform-selective inhibitors
Tatiana P Rogasevskaia et al.
The Journal of biological chemistry, 290(48), 28683-28696 (2015-10-04)
There are a diversity of interpretations concerning the possible roles of phospholipase D and its biologically active product phosphatidic acid in the late, Ca(2+)-triggered steps of regulated exocytosis. To quantitatively address functional and molecular aspects of the involvement of phospholipase
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