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135933

Sigma-Aldrich

5-氯-2-羟基吡啶

97%

同義詞:

5-氯-2-吡啶醇

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About This Item

經驗公式(希爾表示法):
C5H4ClNO
CAS號碼:
分子量::
129.54
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:

化驗

97%

mp

163-165 °C (lit.)

SMILES 字串

Oc1ccc(Cl)cn1

InChI

1S/C5H4ClNO/c6-4-1-2-5(8)7-3-4/h1-3H,(H,7,8)

InChI 密鑰

SZFUWUOHDRMCKD-UHFFFAOYSA-N

一般說明

5-氯-2-羟基吡啶作为供体配体,以两性离子形式存在,即 5-氯吡啶-2-酸酯存在于铜配合物中

應用

用 5-氯-2-羟基吡啶 (5-chloro-2-pyridinol) 研究双香豆素对黄嘌呤脱氢酶的影响 及黄嘌呤脱氢酶还原丝裂霉素 C 的机理

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


分析證明 (COA)

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D L Gustafson et al.
Cancer research, 52(24), 6936-6939 (1992-12-15)
These studies examined the effect of dicumarol on xanthine dehydrogenase (XDH), an enzyme recently shown to bioreduce mitomycin C. Dicumarol, which has previously been shown to inhibit xanthine oxidase (XO), inhibited both XDH and XO mediated conversion of xanthine to
Ji-Xin Yuan et al.
Acta crystallographica. Section C, Crystal structure communications, 58(Pt 4), M270-M272 (2002-04-05)
In the title compound, [Cu(C(5)H(4)ClNO)(2)(C(4)H(4)N(2))(H(2)O)(2)](ClO(4))(2), the Cu atom, which lies on an inversion centre, has an octahedral environment. The pyrazine ligand also lies about an inversion centre and links adjacent Cu atoms into a chain running along the b axis;
D L Gustafson et al.
Cancer research, 53(22), 5470-5474 (1993-11-15)
These studies examined the kinetic and mechanistic parameters of mitomycin C (MMC) bioreduction by xanthine dehydrogenase (XDH), an enzyme recently shown to be capable of MMC activation. The bioreduction of MMC by XDH leads to the formation of 2,7-diaminomitosene (2,7-DM)

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