PCDHA2
protocadherin alpha 2
同義詞:
PCDH-ALPHA2
物種:
Human PCDHA2 (56146), Mouse Pcdha2 (353234), Rat Pcdha2 (393086), cow PCDHA2 (100847133), dog PCDHA2 (487164), domestic guinea pig Pcdha2 (100713044), sheep PCDHA2 (101122274), chicken PCDHA2 (497212)
UniProtKB ID:
基因 ID:
- Human(56146) Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
- Mouse(353234) protocadherin alpha 2
- Rat(393086) protocadherin alpha 2
- cow(100847133) protocadherin alpha 2
- dog(487164) protocadherin alpha 2
- domestic guinea pig(100713044) protocadherin alpha 2
- sheep(101122274) protocadherin alpha 2
- chicken(497212) protocadherin alpha 2
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