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NUDT1

nudix (nucleoside diphosphate linked moiety X)-type motif 1

同義詞:
MTH1
物種:
Human NUDT1 (4521), Mouse Nudt1 (17766), Rat Nudt1 (117260), dog NUDT1 (489894), Zebrafish nudt1 (406727), chicken NUDT1 (416467), domestic guinea pig Nudt1 (100730917), naked mole-rat Nudt1 (101712324), domestic cat NUDT1 (101091068), cow NUDT1 (525496)
UniProtKB ID:
P36639, A4D205, Q6LES7, Q6P0Y6, Q7Z7N6, Q8IV95, Q9UBM0, Q9UBM9
基因 ID:
  • Human(4521) Summary: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
  • Mouse(17766) nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • Rat(117260) nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • dog(489894) nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • Zebrafish(406727) nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • chicken(416467) nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • domestic guinea pig(100730917) nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • naked mole-rat(101712324) nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • domestic cat(101091068) nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • cow(525496) nudix (nucleoside diphosphate linked moiety X)-type motif 1
  • sheep(101119103) nudix (nucleoside diphosphate linked moiety X)-type motif 1

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