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Merck

MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1

同義詞:
IB1, JIP-1, JIP1, PRKM8IP
物種:
Human MAPK8IP1 (9479), Mouse Mapk8ip1 (19099), Rat Mapk8ip1 (116457), domestic cat MAPK8IP1 (101085070), domestic guinea pig Mapk8ip1 (100725179), chicken MAPK8IP1 (423202), sheep MAPK8IP1 (101116934), cow MAPK8IP1 (524806), dog MAPK8IP1 (483640), Horse MAPK8IP1 (100056764)
UniProtKB ID:
Q9UQF2, D3DQP4, O43407
基因 ID:
  • Human(9479) Summary: This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq, May 2011]
  • Mouse(19099) mitogen-activated protein kinase 8 interacting protein 1
  • Rat(116457) mitogen-activated protein kinase 8 interacting protein 1
  • domestic cat(101085070) mitogen-activated protein kinase 8 interacting protein 1
  • domestic guinea pig(100725179) mitogen-activated protein kinase 8 interacting protein 1
  • chicken(423202) mitogen-activated protein kinase 8 interacting protein 1
  • sheep(101116934) mitogen-activated protein kinase 8 interacting protein 1
  • cow(524806) mitogen-activated protein kinase 8 interacting protein 1
  • dog(483640) mitogen-activated protein kinase 8 interacting protein 1
  • Horse(100056764) mitogen-activated protein kinase 8 interacting protein 1
  • naked mole-rat(101705667) mitogen-activated protein kinase 8 interacting protein 1

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Antibodies

產品編號
描述
物種活性
應用
SAB4503651
Anti-JIP1 antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
immunofluorescence
immunohistochemistry
western blot