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Merck

INPP5D

inositol polyphosphate-5-phosphatase, 145kDa

同義詞:
SHIP, SHIP-1, SHIP1, SIP-145, hp51CN
物種:
Human INPP5D (3635), Mouse Inpp5d (16331), Rat Inpp5d (54259), chicken INPP5D (424745), Zebrafish inpp5d (559103), naked mole-rat Inpp5d (101711777), domestic guinea pig Inpp5d (100722743), sheep INPP5D (101112941), Horse INPP5D (100064896), cow INPP5D (507329) ...更多
UniProtKB ID:
Q92835, O00145, Q13544, Q13545, Q6P5A4, Q92656, Q9UE80
基因 ID:
  • Human(3635) Summary: This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Mouse(16331) inositol polyphosphate-5-phosphatase D
  • Rat(54259) inositol polyphosphate-5-phosphatase D
  • chicken(424745) inositol polyphosphate-5-phosphatase, 145kDa
  • Zebrafish(559103) inositol polyphosphate-5-phosphatase, 145kDa
  • naked mole-rat(101711777) inositol polyphosphate-5-phosphatase, 145kDa
  • domestic guinea pig(100722743) inositol polyphosphate-5-phosphatase, 145kDa
  • sheep(101112941) inositol polyphosphate-5-phosphatase, 145kDa
  • Horse(100064896) inositol polyphosphate-5-phosphatase, 145kDa
  • cow(507329) inositol polyphosphate-5-phosphatase, 145kDa
  • domestic cat(101100500) inositol polyphosphate-5-phosphatase, 145kDa
  • dog(100688270) inositol polyphosphate-5-phosphatase, 145kDa

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Antibodies

產品編號
描述
物種活性
應用
SAB4504067
抗-磷酸化-SHIP1 (pTyr1021) 兔抗, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
western blot