FGFR1
fibroblast growth factor receptor 1
同義詞:
BFGFR, CD331, CEK, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, KAL2, N-SAM, OGD, bFGF-R-1
物種:
Human FGFR1 (2260), Mouse Fgfr1 (14182), Rat Fgfr1 (79114), Domestic Rabbit FGFR1 (100351861), cow FGFR1 (281768), Horse FGFR1 (100057614), dog FGFR1 (475582), chicken FGFR1 (396516), naked mole-rat Fgfr1 (101700324), domestic guinea pig Fgfr1 (100731156)
UniProtKB ID:
基因 ID:
- Human(2260) Summary: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
- Mouse(14182) fibroblast growth factor receptor 1
- Rat(79114) Fibroblast growth factor receptor 1
- Domestic Rabbit(100351861) fibroblast growth factor receptor 1
- cow(281768) fibroblast growth factor receptor 1
- Horse(100057614) fibroblast growth factor receptor 1
- dog(475582) fibroblast growth factor receptor 1
- chicken(396516) fibroblast growth factor receptor 1
- naked mole-rat(101700324) fibroblast growth factor receptor 1
- domestic guinea pig(100731156) fibroblast growth factor receptor 1
- domestic cat(101086055) fibroblast growth factor receptor 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
產品編號
描述
物種活性
應用
抗phospho-FGFR-1 (Tyr653/Tyr654)抗体, from rabbit, purified by affinity chromatography,
物種活性
xenopus, bovine, chicken, human, mouse, rat, zebrafish
應用
cell based assay
western blot
western blot
Anti-Fibroblast Growth Factor Receptor-1 antibody produced in rabbit, ~1 mg/mL, affinity isolated antibody, buffered aqueous solution,
物種活性
human
應用
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-FGFR1 antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-FGFR1 antibody produced in rabbit, affinity isolated antibody,
物種活性
human, mouse, rat
應用
ELISA
western blot
western blot
ANTI-FGFR1 antibody produced in mouse, clone 3C9, purified immunoglobulin, buffered aqueous solution,
物種活性
human
應用
ELISA
western blot
western blot
Small Molecule - Inhibitor
Proteins
產品編號
描述
物種
FGFR1 Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human FGFR1 amino acids 456-765, for use in Kinase Assays.,
物種
human
FGFR1 (V561M) Protein, active, 10 µg, Active, N-terminal GST-tagged, recombinant, human FGFR1 amino acids 456 -765 containing the V561 mutation. For use in Enzyme Assays.,
物種
human
FGFR1 (FLT2) (399-822), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物種
human