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Merck

DIO3

deiodinase, iodothyronine, type III

同義詞:
5DIII, D3, DIOIII, TXDI3
物種:
Human DIO3 (1735), Mouse Dio3 (107585), Rat Dio3 (29475), naked mole-rat Dio3 (101697914), Domestic Rabbit DIO3 (100357267), Horse DIO3 (100146344), sheep DIO3 (100142657), dog DIO3 (612596), domestic cat DIO3 (101094186), chicken DIO3 (395939)
UniProtKB ID:
P55073, Q8WVN5
基因 ID:
  • Human(1735) Summary: The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
  • Mouse(107585) deiodinase, iodothyronine type III
  • Rat(29475) deiodinase, iodothyronine, type III
  • naked mole-rat(101697914) deiodinase, iodothyronine, type III
  • Domestic Rabbit(100357267) deiodinase, iodothyronine, type III
  • Horse(100146344) deiodinase, iodothyronine, type III
  • sheep(100142657) deiodinase, iodothyronine, type III
  • dog(612596) deiodinase, iodothyronine, type III
  • domestic cat(101094186) deiodinase, iodothyronine, type III
  • chicken(395939) deiodinase, iodothyronine, type III
  • cow(494549) deiodinase, iodothyronine, type III

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Antibodies

產品編號
描述
物種活性
應用
SAB1301592
ANTI-DIO3 (C-TERM) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
物種活性
human
應用
immunohistochemistry
western blot