COL25A1
collagen, type XXV, alpha 1
同義詞:
AMY, CLAC, CLAC-P, CLACP
物種:
Human COL25A1 (84570), Mouse Col25a1 (77018), Rat Col25a1 (687064), dog COL25A1 (610442), domestic cat COL25A1 (101089352), chicken COL25A1 (429900), domestic guinea pig Col25a1 (100717264), naked mole-rat Col25a1 (101706837), Horse COL25A1 (100072894), cow COL25A1 (615661)
UniProtKB ID:
基因 ID:
- Human(84570) Summary: This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
- Mouse(77018) collagen, type XXV, alpha 1
- Rat(687064) collagen, type XXV, alpha 1
- dog(610442) collagen, type XXV, alpha 1
- domestic cat(101089352) collagen, type XXV, alpha 1
- chicken(429900) collagen, type XXV, alpha 1
- domestic guinea pig(100717264) collagen, type XXV, alpha 1
- naked mole-rat(101706837) collagen, type XXV, alpha 1
- Horse(100072894) collagen, type XXV, alpha 1
- cow(615661) collagen, type XXV, alpha 1
- sheep(101120576) collagen, type XXV, alpha 1
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