CARD8
caspase recruitment domain family, member 8
同義詞:
CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN
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基因 ID:
- Human(22900) Summary: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
- dog(491519) caspase recruitment domain family, member 8
- domestic cat(101093817) caspase recruitment domain family, member 8
- chicken(416998) caspase recruitment domain family, member 8
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Small Molecule - Substrate
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