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  • Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.

Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.

Bioorganic & medicinal chemistry letters (2010-02-23)
Vincent Rerat, Sophie Laurent, Carmen Burtéa, Benoît Driesschaert, Vincent Pourcelle, Luce Vander Elst, Robert N Muller, Jacqueline Marchand-Brynaert
PMID20172716
ABSTRACT

Ultrasmall particles of iron oxide (USPIOs) coated with 3,3'-bis(phosphonate)propionic acid were covalently coupled to a home-made Arg-Gly-Asp (RGD) peptidomimetic molecule via a short oligoethylene-glycol (OEG) spacer. The conjugation rate was measured by X-ray photoelectron spectroscopy (XPS). The particle size and magnetic characteristics were kept. Our novel conjugate targeted efficiently Jurkat cells (increase of 229% vs the control).