SRP6553

CIRBP/Cold-inducible RNA-binding protein human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonym(s): A18HNRNP, CIRP
• UNSPSC Code: 12352202
• NACRES: NA.32

Properties

• biological source: human
• recombinant: expressed in E. coli
• Assay: ≥90% (SDS-PAGE)
• form: lyophilized
• mol wt: 20.5 kDa
• packaging: pkg of 1 mg; pkg of 20 μg
• impurities: ≤1 EU/μg endotoxin (LAL test)
• UniProt accession no.: Q14011
• shipped in: wet ice
• storage temp.: −70°C
• Gene Information: human ... CIRBP(1153)

Description

General description

CIRBP, also known as cold-inducible RNA-binding protein, plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. CIRBP responds to a wide array of cellular stresses, including short wavelength ultraviolet light (UVC), at the transcriptional and post-translational level. It acts as a translational activator. CIRBP can bind the 3′untranslated region of specific transcripts to stabilize them and facilitate their transport to ribosomes for translation. CIRBP affects NF-κB signaling as opposed to IL1B mRNA stability directly.

Physical form

Lyophilized from sterile 20 mM Tris, 500 mM NaCl, 0.25 M Imidazole, 20% glycerol.

Reconstitution

Detailed reconstitution instructions are sent along with the product

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Danger
• Hazard Statements: H315,H319,H360D
• Precautionary Statements: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable