SAB4700188
Monoclonal Anti-CD44 antibody produced in rat
clone IM7, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-Pgp-1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
Recommended Products
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
IM7, monoclonal
form
buffered aqueous solution
species reactivity
mouse, horse, canine, human, feline
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... CD44(960)
General description
The CD44 (cell-surface glycoprotein) gene with 20 exons is mapped to human chromosome 11p13. The gene codes for a transmembrane glycoprotein.
The rat monoclonal antibody IM7 reacts with CD44 antigen (Phagocyte glycoprotein 1), an 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes. The antibody reacts with all isoforms of mouse CD44.
Immunogen
Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1
Application
Monoclonal Anti-CD44 antibody produced in rat has been used in immunohistochemistry.
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Biochem/physiol Actions
CD44 (cell-surface glycoprotein) is involved in cell-cell and cell-extracellular matrix interactions. It plays an important role in lymphocyte homing and lymphocyte activation. It also acts as a metastasis suppressor gene for prostatic cancer. Overexpression of CD44 leads to esophageal squamous cell carcinoma (ESCC). CD44 inhibits macrophage multinucleation by interacting with its ligands, hyaluronic acid, chondroitin sulfates and osteopontin. 100kDa form of CD44, facilitates the binding of poliovirus to HeLa cells. In addition, it also implicated in the infection of mononuclear phagocytes by human immunodeficiency virus (HIV).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Find documentation for the products that you have recently purchased in the Document Library.
A rare missense variant in RCL1 segregates with depression in extended families
Amin N
Molecular Psychiatry (2017)
Heli Li et al.
Journal of immunology research, 2018, 4807145-4807145 (2019-01-24)
The immunologic interaction between parenchyma cells and encircling inflammatory cells is thought to be the most important mechanism of biliary damage and repair in primary sclerosing cholangitis (PSC). Monocytes/macrophages as master regulators of hepatic inflammation have been demonstrated to contribute
Gongcai Qiu et al.
International journal of oncology, 55(1), 45-58 (2019-05-07)
The present study aimed to explore the long non‑coding RNA (lncRNA) expression profiles and correlation of lnc‑PKD2‑2‑3 with tumor features and prognosis, and to investigate its effect on regulating cancer‑cell stemness and its potential as a cancer stem cell (CSC) marker
Guoliang Zhang et al.
Acta biochimica et biophysica Sinica, 46(7), 540-547 (2014-05-23)
Differentiation of monocytes into macrophages is an important process under physiological and pathological conditions, but the underlying mechanism of monocyte differentiation is not completely clear. Some adhesion molecules have been reported to play an important role in cell differentiation. CD44
Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance
Whelan KA
Oncogene, 36, 4843-4858 (2017)
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