Skip to Content
Merck
All Photos(1)

Documents

938882

Sigma-Aldrich

NanoFabTx Polymers for Microneedles

new

Hyaluronic acid sodium salt

Synonym(s):

Hyaluronic acid sodium salt

Sign Into View Organizational & Contract Pricing


About This Item

Linear Formula:
(C14H21NaNO11)n
CAS Number:

Quality Level

Assay

≥90%

mol wt

100-150 kDa

storage temp.

2-8°C

SMILES string

O[C@H]1[C@H](O[C@@H]2O[C@H](C(O[Na])=O)[C@@H](OC)[C@H](O)[C@H]2O)[C@@H](NC(C)=O)[C@H](C)O[C@@H]1CO

Application

NanoFabTx Polymers for Microneedles are carefully selected polymers that can be used to formulate microneedle patches. Microneedles are tiny projections of needles approximately 400-800um in length arranged in a small 1cm x 1cm patch. Microneedles are composed of blends of synthetic or natural polymers at suitable concentrations. Sodium hyaluronic acid (HA) is the derivate of a natural polymer and is a natural polysaccharide. It is a water-soluble polymer and is available in different molecular weights. The formation of the microneedles depends on the molecular weight and concentration of HA.


The NanoFabTx Polymers for Microneedles can be used with the microneedle templates to formulate microneedle that can be used for several applications, such as delivering various therapeutic molecules and vaccine antigens via the skin. The selected polymer will enable users to:

1)save time in selecting the polymer and provide a starting point to formulate microneedles by avoiding lengthy trial-and-error optimization.

2)formulate microneedles for various drug delivery applications.

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

A dual-delivery platform for vaccination using antigen-loaded nanoparticles in dissolving microneedles
Gomes K B, et al.
International Journal of Pharmaceutics, 613, 121393-121393 (2022)
Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development
Larra?eta E, et al.
Materials Science & Engineering. R, Reports : A Review Journal, 104, 1-32 (2016)
Keegan Braz Gomes et al.
International journal of pharmaceutics, 613, 121393-121393 (2021-12-21)
Effective vaccines delivered via painless methods would revolutionize the way people approach vaccinations. This study focused on the development of fast-dissolving microneedles (MNs) to deliver antigen-loaded sustained release polymeric nanoparticles (NPs), achieving a dual-delivery platform for vaccination through the skin.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service