TSN
translin
Synonyms:
BCLF-1, C3PO, RCHF1, REHF-1, TBRBP, TRSLN
Species:
Human TSN (7247), Mouse Tsn (22099), Rat Tsn (60381), Zebrafish tsn (334107), chicken TSN (395955), chicken TSN (100309740), dog TSN (483876), domestic cat TSN (101099390), cow TSN (509943), sheep TSN (101116021) ...More
UniProtKB ID:
Gene ID:
- Human(7247) Summary: This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
- Mouse(22099) translin
- Rat(60381) translin
- Zebrafish(334107) translin
- chicken(395955) translin
- chicken(100309740) Tibia strain
- dog(483876) translin
- domestic cat(101099390) translin
- cow(509943) translin
- sheep(101116021) translin
- domestic guinea pig(100716411) translin
- naked mole-rat(101722350) translin
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