SAV1
salvador homolog 1 (Drosophila)
Synonyms:
SAV, WW45, WWP4
Species:
Human SAV1 (60485), Mouse Sav1 (64010), Rat Sav1 (299116), chicken SAV1 (423578), dog SAV1 (480319), domestic cat SAV1 (101096154), naked mole-rat Sav1 (101726669), Horse SAV1 (100066557), sheep SAV1 (101104666), Domestic Rabbit SAV1 (100350937) ...More
UniProtKB ID:
Gene ID:
- Human(60485) Summary: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]
- Mouse(64010) salvador homolog 1 (Drosophila)
- Rat(299116) salvador homolog 1 (Drosophila)
- chicken(423578) salvador homolog 1 (Drosophila)
- dog(480319) salvador homolog 1 (Drosophila)
- domestic cat(101096154) salvador homolog 1 (Drosophila)
- naked mole-rat(101726669) salvador homolog 1 (Drosophila)
- Horse(100066557) salvador homolog 1 (Drosophila)
- sheep(101104666) salvador homolog 1 (Drosophila)
- Domestic Rabbit(100350937) salvador homolog 1 (Drosophila)
- domestic guinea pig(100728249) salvador homolog 1 (Drosophila)
- Zebrafish(447821) salvador homolog 1 (Drosophila)
- cow(516557) salvador homolog 1 (Drosophila)
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