RAD50
RAD50 homolog (S. cerevisiae)
Synonyms:
NBSLD, RAD502, hRad50
Species:
Human RAD50 (10111), Mouse Rad50 (19360), Rat Rad50 (64012), domestic guinea pig Rad50 (100719847), domestic cat RAD50 (101095875), cow RAD50 (788127), fruit fly rad50 (37564), naked mole-rat Rad50 (101719180), Thale Cress RAD50 (817756), chicken RAD50 (416329) ...More
UniProtKB ID:
Gene ID:
- Human(10111) Summary: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.[provided by RefSeq, Apr 2010]
- Mouse(19360) RAD50 homolog (S. cerevisiae)
- Rat(64012) RAD50 homolog (S. cerevisiae)
- domestic guinea pig(100719847) RAD50 homolog (S. cerevisiae)
- domestic cat(101095875) RAD50 homolog (S. cerevisiae)
- cow(788127) RAD50 homolog (S. cerevisiae)
- fruit fly(37564) CG6339 gene product from transcript CG6339-RE
- naked mole-rat(101719180) RAD50 homolog (S. cerevisiae)
- Thale Cress(817756) DNA repair protein RAD50
- chicken(416329) RAD50 homolog (S. cerevisiae)
- dog(474674) RAD50 homolog (S. cerevisiae)
- Zebrafish(553029) RAD50 homolog (S. cerevisiae)
- sheep(101123035) RAD50 homolog (S. cerevisiae)
- Horse(100063198) RAD50 homolog (S. cerevisiae)
- Domestic Rabbit(100328725) RAD50 homolog (S. cerevisiae)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-RAD50 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
western blot
western blot
Anti-Rad50 Antibody, clone 13B3/2C6, clone 13B3/2C6, Upstate®, from mouse,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
western blot
western blot