NR1I3
nuclear receptor subfamily 1, group I, member 3
Synonyms:
CAR, CAR1, MB67
Species:
Human NR1I3 (9970), Mouse Nr1i3 (12355), Rat Nr1i3 (65035), domestic cat NR1I3 (101088457), cow NR1I3 (493711), chicken NR1I3 (395439), naked mole-rat Nr1i3 (101699988), dog NR1I3 (488653), domestic guinea pig Nr1i3 (100714102), sheep NR1I3 (101104874)
UniProtKB ID:
Gene ID:
- Human(9970) Summary: This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(12355) nuclear receptor subfamily 1, group I, member 3
- Rat(65035) nuclear receptor subfamily 1, group I, member 3
- domestic cat(101088457) nuclear receptor subfamily 1, group I, member 3
- cow(493711) nuclear receptor subfamily 1, group I, member 3
- chicken(395439) nuclear receptor subfamily 1, group I, member 3
- naked mole-rat(101699988) nuclear receptor subfamily 1, group I, member 3
- dog(488653) nuclear receptor subfamily 1, group I, member 3
- domestic guinea pig(100714102) nuclear receptor subfamily 1, group I, member 3
- sheep(101104874) nuclear receptor subfamily 1, group I, member 3
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