MATK
megakaryocyte-associated tyrosine kinase
Synonyms:
CHK, CTK, HHYLTK, HYL, HYLTK, Lsk
Species:
Human MATK (4145), Mouse Matk (17179), Rat Matk (60450), cow MATK (504668), sheep MATK (101117161), domestic guinea pig Matk (100729756), Thale Cress matK (844797), Zebrafish matk (567405), chicken MATK (769076), dog MATK (611999) ...More
UniProtKB ID:
Gene ID:
- Human(4145) Summary: The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
- Mouse(17179) megakaryocyte-associated tyrosine kinase
- Rat(60450) megakaryocyte-associated tyrosine kinase
- cow(504668) megakaryocyte-associated tyrosine kinase
- sheep(101117161) megakaryocyte-associated tyrosine kinase
- domestic guinea pig(100729756) megakaryocyte-associated tyrosine kinase
- Thale Cress(844797) maturase K
- Zebrafish(567405) megakaryocyte-associated tyrosine kinase
- chicken(769076) megakaryocyte-associated tyrosine kinase
- dog(611999) megakaryocyte-associated tyrosine kinase
- domestic cat(101099024) megakaryocyte-associated tyrosine kinase
- naked mole-rat(101718779) megakaryocyte-associated tyrosine kinase
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