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EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3

Synonyms:
PEK, PERK, WRS
Species:
UniProtKB ID:
Gene ID:
  • Human(9451) Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]
  • Mouse(13666) eukaryotic translation initiation factor 2 alpha kinase 3
  • Rat(29702) eukaryotic translation initiation factor 2 alpha kinase 3
  • Horse(100066488) eukaryotic translation initiation factor 2-alpha kinase 3
  • domestic cat(101095973) eukaryotic translation initiation factor 2-alpha kinase 3
  • cow(535820) eukaryotic translation initiation factor 2-alpha kinase 3
  • Zebrafish(559564) eukaryotic translation initiation factor 2-alpha kinase 3
  • dog(475756) eukaryotic translation initiation factor 2-alpha kinase 3
  • chicken(422930) eukaryotic translation initiation factor 2-alpha kinase 3
  • sheep(101110042) eukaryotic translation initiation factor 2-alpha kinase 3
  • domestic guinea pig(100725836) eukaryotic translation initiation factor 2-alpha kinase 3
  • naked mole-rat(101713561) eukaryotic translation initiation factor 2-alpha kinase 3

Custom & Knockdown Gene Products

  • siRNA

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  • Custom Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
Anti-PERK Antibody, clone 4F6.1, clone 4F6.1, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-phospho-PEK/PERK (pThr981) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-PERK (N-terminal) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
mouse, rat
Application
western blot
Anti-PERK (C-terminal) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
western blot

Proteins

Product Number
Description
Species
PEK, active, ,
Species
human
PEK Protein, active, 10 µg, ,
Species
human
EIF2AK3 (563-1115), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human EIF2AK3, AC104134.2,
Species
human