DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Synonyms:
DYRK, DYRK1, HP86, MNB, MNBH, MRD7
Species:
Human DYRK1A (1859), Mouse Dyrk1a (13548), Rat Dyrk1a (25255), Horse DYRK1A (100051707), dog DYRK1A (487755), domestic cat DYRK1A (101100581), domestic guinea pig Dyrk1a (100714823), naked mole-rat Dyrk1a (101719681), cow DYRK1A (532989), chicken DYRK1A (395233) ...More
UniProtKB ID:
Gene ID:
- Human(1859) Summary: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(13548) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
- Rat(25255) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- Horse(100051707) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- dog(487755) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- domestic cat(101100581) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- domestic guinea pig(100714823) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- naked mole-rat(101719681) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- cow(532989) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- chicken(395233) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- sheep(101117130) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
- Domestic Rabbit(100350296) dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-DYRK1A antibody produced in mouse, clone 7D10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
mouse
Application
ELISA
western blot
western blot
Anti-DYRK1A Antibody, clone 7F3, clone 7F3, from mouse,
Species Reactivity
human, monkey, rat
Application
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-DYRK1A (N-terminal) antibody produced in rabbit, ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-DYRK1A Mouse mAb (7D10), liquid, clone 7D10, Calbiochem®,
Species Reactivity
human, mouse, rat
Application
Anti-DYRK1A Antibody, clone 8D9, clone 8D9, from mouse,
Species Reactivity
chicken, human, mouse, rat
Application
western blot
Small Molecule - Inhibitor
Product Number
Description
Species