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Merck

CHD8

chromodomain helicase DNA binding protein 8

Synonyms:
AUTS18, HELSNF1
Species:
Human CHD8 (57680), Mouse Chd8 (67772), Rat Chd8 (65027), Zebrafish chd8 (568214), dog CHD8 (475401), domestic cat CHD8 (101097402), cow CHD8 (507111), Horse CHD8 (100059337), sheep CHD8 (101109181), domestic guinea pig Chd8 (100713580)
UniProtKB ID:
Q9HCK8, Q4G0D8, Q68DQ0, Q6DKH9, Q6P440, Q6ZNL7, Q8N3Z9, Q8NCY4
Gene ID:
  • Human(57680) Summary: This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
  • Mouse(67772) chromodomain helicase DNA binding protein 8
  • Rat(65027) chromodomain helicase DNA binding protein 8
  • Zebrafish(568214) chromodomain helicase DNA binding protein 8
  • dog(475401) chromodomain helicase DNA binding protein 8
  • domestic cat(101097402) chromodomain helicase DNA binding protein 8
  • cow(507111) chromodomain helicase DNA binding protein 8
  • Horse(100059337) chromodomain helicase DNA binding protein 8
  • sheep(101109181) chromodomain helicase DNA binding protein 8
  • domestic guinea pig(100713580) chromodomain helicase DNA binding protein 8
  • naked mole-rat(101698950) chromodomain helicase DNA binding protein 8

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