CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
Synonyms:
Species:
Human CAD (790), Mouse Cad (69719), Rat Cad (24240), fruit fly cad (35341), Zebrafish cad (266992), chicken CAD (428659), dog CAD (483009), domestic cat CAD (101091102), Horse CAD (100055366), cow CAD (504261) ...More
UniProtKB ID:
Gene ID:
- Human(790) Summary: The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq, Jul 2008]
- Mouse(69719) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- Rat(24240) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- fruit fly(35341) caudal
- Zebrafish(266992) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- chicken(428659) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- dog(483009) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- domestic cat(101091102) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- Horse(100055366) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- cow(504261) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- sheep(101115776) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- Domestic Rabbit(100352236) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- domestic guinea pig(100727133) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
- naked mole-rat(101710382) carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
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