U3885

UK-78282 monohydrochloride

≥98% (HPLC)

• Synonym(s): 4-[(Diphenylmethoxy)methyl]-1-[3-(4-methoxyphenyl)propyl]-piperidine monohydrochloride
• Empirical Formula (Hill Notation): C₂₉H₃₅NO₂HCl
• CAS Number: 136647-02-4
• Molecular Weight: 466.05
• MDL number: MFCD16875438
• UNSPSC Code: 12352200
• PubChem Substance ID: 329827628
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to off-white
• solubility: DMSO: >10 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: Cl.COc1ccc(CCCN2CCC(CC2)COC(c3ccccc3)c4ccccc4)cc1
• InChI: 1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H
• InChI key: ZZSQARULZYQMIG-UHFFFAOYSA-N

Description

Biochem/physiol Actions

UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

UK-78282 monohydrochloride dissolves in DMSO at a concentration >10 mg/ml.

Safety Information

• Pictograms: GHS07,GHS09
• Signal Word: Warning
• Hazard Statements: H319,H400
• Precautionary Statements: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
• Hazard Classifications: Aquatic Acute 1 - Eye Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable