P0393
Protein Kinase Inhibitor from porcine heart
1-3 inhibitor U/μg protein, lyophilized powder
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About This Item
MDL number:
UNSPSC Code:
12352202
Recommended Products
biological source
Porcine heart
form
lyophilized powder
specific activity
1-3 inhibitor U/μg protein
composition
Protein, ~50% biuret
storage temp.
2-8°C
Biochem/physiol Actions
These proteins bind to the catalytic subunit of cyclic-AMP dependent protein kinase, displacing the regulatory subunit and inhibiting phosphorylating activity. The cyclic-AMP binding capacity of the regulatory subunit is enhanced. Many other proteins exhibit this enhancement ability, too (Brostrom, C.O. and Kon, C., Anal. Biochem., 58, 459 [1974]).
Packaging
Package size based on protein content.
Unit Definition
One unit will transfer 1.0 picomole (10-12 mol) of phosphate from γ-32P-ATP to hydrolyzed and partially dephosphorylated casein (Product No. C 4765) per min at pH 6.5 at 30 °C.
Physical form
Supplied as lyophilized powder containing 30% glycerophosphate and 20% EDTA.
Preparation Note
Fractionated essentially by procedure of Walsh, D.A., et al., J. Biol. Chem., 246, 1977 (1971).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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