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Key Documents

250A-1

Sigma-Aldrich

Factor VIII-R Ag. Rabbit Polyclonal Antibody

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100
500

conjugate

unconjugated

antibody form

Ig fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (250A-14)
vial of 0.5 mL concentrate (250A-15)
bottle of 1.0 mL predilute (250A-17)
vial of 1.0 mL concentrate (250A-16)
bottle of 7.0 mL predilute (250A-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50

control

placenta

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic

Gene Information

human ... VWF(7450)

General description

Factor VIII-Related Antigen or von Willebrand factor is a glycoprotein associated with hemostasis in promoting the adhesion of platelets. Anti-Factor VIII Related Antigen reactivity is seen in endothelial cells, hemangioma, and the majority of tumors of endothelial origin such as Kaposi’s sarcoma and angiosarcoma.

Quality


IVD
IVD
IVD
RUO

Linkage

Factor VIII-R Ag. (polyclonal) Positive Control Slides, Product No. 250S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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K H Fulling et al.
Cancer, 51(6), 1107-1118 (1983-03-15)
Two cases of neoplastic angioendotheliomatosis are described. Both patients presented with subacute development of dementia punctuated by focal neurologic signs. Postmortem examination in both cases disclosed a vasculocentric distribution of neoplastic cells in many organs. Two characteristic histologic patterns were
J Ansell et al.
Cancer, 50(8), 1506-1512 (1982-10-15)
The case history of a patient with diffuse histiocytic lymphoma and skin lesions characteristic of malignant angioendotheliomatosis is reported. The patient initially responded to aggressive chemotherapy but quickly had a relapse, CNS disease developed, and the patient died one year
X W Bian et al.
Analytical and quantitative cytology and histology, 22(3), 267-274 (2000-06-29)
To investigate the correlation of angiogenic factor expression levels with the degrees of malignancy and vascularity and their clinicopathologic significance in astrocytomas. Factor VIII-related antigen (FVIII-RAg) was used as the marker of endothelia and basic fibroblast growth factor (bFGF); FGF
U K Zätterström et al.
Head & neck, 17(4), 312-318 (1995-07-01)
The progression of tumor growth requires the recruitment of new blood vessels. It has been suggested that the degree of neovascularization would correlate with clinical prognosis. The purpose of the present study was to ascertain whether tumor vascularization correlated with
J Bhawan et al.
Cancer, 55(3), 570-576 (1985-02-01)
A patient was diagnosed as having angioendotheliomatosis proliferans systemisata (APS) based on characteristic clinical and histologic features. A few days later, malignant lymphoma involving the gut was discovered. Immunohistochemical and electronmicroscopic studies confirmed the nonendothelial and lymphoid nature of intravascular
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